Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.

ABSTRACT:

Abstract

The ability of virally suppressive antiretroviral therapy use to extend the life span of people with HIV (PWH) implies that the age of PWH will also increase. Among PWH, extended survival comes at a cost of earlier onset and increased rates of aging-associated comorbidities and geriatric syndromes, with persistent inflammation and immune dysregulation consequent to chronic HIV infection and to antiretroviral therapy use contributing to an overall decrease in health span. The geroscience hypothesis proposes that the root causes of most aging-related chronic diseases and conditions is the aging process itself. Hence, therapeutically targeting fundamental aging processes could have a greater impact on alleviating or delaying aging-associated comorbidities than addressing each

SUBMITTER: Masters MC 

PROVIDER: S-EPMC8751288 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature