Comprehensive analysis of expression profile and prognostic significance of interferon regulatory factors in pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified. This study aimed to explorer the expression profile, prognostic significance, and biological function of IRFs in PC.

Results

We observed that the levels of IRF2, 6, 7, 8, and 9 were elevated in tumor compared to normal tissues in PC. IRF7 expression was significantly associated with patients' pathology stage in PC. PC patients with high IRF2, low IRF3, and high IRF6 levels had significantly poorer overall survival. High mRNA expr

SUBMITTER: Zhang K 

PROVIDER: S-EPMC8751298 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature