MiR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy.

ABSTRACT:

Background

Accumulating evidence has revealed that aberrant microRNA (miRNA) expression can affect the development of chemotherapy drug resistance by modulating the expression of relevant target proteins. Emerging evidence has demonstrated that miR-133a participates in the tumorigenesis of various cancers. However, whether miR-133a is associated with cisplatin resistance in ovarian cancer remains unclear.

Objective

To investigate the role of miR-133a in the development of cisplatin resistance in ovarian cancer.

Methods

MiR-133a expression in cisplatin-resistant ovarian cancer cell lines was assessed by reverse-transcription quantitative PCR (RT-qPCR). A cell counting kit-8 (CCK-8) assay was used to evaluate the viability of tumour cells treated with cisplatin in the p

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8751326 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature