LncRNA TP73-AS1 promotes nasopharyngeal carcinoma progression through targeting miR-342-3p and M2 polarization via exosomes.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) is a deadly cancer, mainly presenting in southeast and east Asia. Long noncoding RNAs (lncRNAs) play essential roles in cancer progression. Exosomes are critical for intercellular communication. Thus, the aim of this study was to identify the functional lncRNAs in NPC and its relevant mechanisms.

Methods

Data from public databases were utilized to screen for functional lncRNAs in NPC. Functional and mechanical experiments were performed to determine the role of lncRNAs in NPC and its relative molecular mechanisms. Exosomes derived from NPC cells were isolated to determine their function in tumor-associated macrophages.

Results

LncRNA TP73-AS1 was increased in NPC cells and tissues and was associated with a poor prognosis. TP73

SUBMITTER: Yao H 

PROVIDER: S-EPMC8751349 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature