Evolution of the repression mechanisms in circadian clocks.

ABSTRACT:

Background

Circadian (daily) timekeeping is essential to the survival of many organisms. An integral part of all circadian timekeeping systems is negative feedback between an activator and repressor. However, the role of this feedback varies widely between lower and higher organisms.

Results

Here, we study repression mechanisms in the cyanobacterial and eukaryotic clocks through mathematical modeling and systems analysis. We find a common mathematical model that describes the mechanism by which organisms generate rhythms; however, transcription's role in this has diverged. In cyanobacteria, protein sequestration and phosphorylation generate and regulate rhythms while transcription regulation keeps proteins in proper stoichiometric balance. Based on recent experimental work,

SUBMITTER: Tyler J 

PROVIDER: S-EPMC8751359 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature