Tertiary lymphoid structure stratifies glioma into three distinct tumor subtypes.

ABSTRACT:

Objective

Tertiary lymphoid structure (TLS), also known as ectopic lymphoid organs, are found in cancer, chronic inflammation, and autoimmune diseases. However, the heterogeneity of TLS in gliomas is unclear. Therefore, it is necessary to identify TLS differences and define TLS subtypes.

Methods

The TLS gene profile of 697 gliomas from The Cancer Genome Atlas (TCGA) was used for consensus clustering to identify robust clusters, and the reproducibility of the stratification method was assessed in Chinese Glioma Genome Atlas (CGGA) cohort1, CGGA_cohort2, and GSE16011. Analyses of clinical characteristics, immune infiltration, and potential biological functions were performed for each subtype.

Results

Three resulting clusters (A, B, and C) were identified based on consen

SUBMITTER: Zhou X 

PROVIDER: S-EPMC8751592 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature