Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient mice.

ABSTRACT: Pelvic organ prolapse is a worldwide health problem to elderly women. Understanding its pathogenesis and an ideal animal model are crucial to developing promising treatments. The present study aimed to investigate new clinical significance and detailed mechanism of pelvic organ prolapse by comparing the structural, functional and molecular dysfunctions of pelvic organ prolapse in patient and Loxl1 deficient mice. Our results showed that human vagina tissues from prolapsed site showed disarranged collagen and elastic fibers compared with the non-prolapse tissue. A gene ontology (GO) analysis of differentially expressed genes revealed molecular changes mainly related to inflammatory response and extracellular matrix (ECM) organization. While the mice lacking Loxl1 developed sta

SUBMITTER: Li Y 

PROVIDER: S-EPMC8751609 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature