Fecal Microbiome Composition Does Not Predict Diet-Induced TMAO Production in Healthy Adults.

ABSTRACT: Background Trimethylamine-N-oxide (TMAO) is a small molecule derived from the metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease. Plasma TMAO increases following consumption of red meat. This metabolic change is thought to be partly because of the expansion of gut microbes able to use nutrients abundant in red meat. Methods and Results We used data from a randomized crossover study to estimate the degree to which TMAO can be estimated from fecal microbial composition. Healthy participants received a series of 3 diets that differed in protein source (red meat, white meat, and non-meat), and fecal, plasma, and urine samples were collected following 4 weeks of exposure to each diet. TMAO was quantitated in plasma and urine, while shotgun metagenom

SUBMITTER: Ferrell M 

PROVIDER: S-EPMC8751816 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature