Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms.

ABSTRACT: Background The pathogenesis of vascular stiffening and hypertension is marked by non-compliance of vessel wall because of deposition of collagen fibers, loss of elastin fibers, and increased vascular thickening. Rho/Rho-associated coiled-coil containing kinases 1 and 2 (ROCK1 and ROCK2) have been shown to regulate cellular contraction and vascular remodeling. However, the role of ROCK isoforms in mediating pathogenesis of vascular stiffening and hypertension is not known. Methods and Results Hemizygous Rock mice (Rock1^+/- and Rock2^+/-) were used to determine the role of ROCK1 and ROCK2 in age-related vascular dysfunction. Both ROCK activity and aortic stiffness increased to a greater extent with age in wild-type mice compared with that of Rock1

SUBMITTER: Li Y 

PROVIDER: S-EPMC8751888 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature