Leveraging Genetic Data to Elucidate the Relationship Between COVID-19 and Ischemic Stroke.

ABSTRACT: Background The relationship between COVID-19 and ischemic stroke is poorly understood due to potential unmeasured confounding and reverse causation. We aimed to leverage genetic data to triangulate reported associations. Methods and Results Analyses primarily focused on critical COVID-19, defined as hospitalization with COVID-19 requiring respiratory support or resulting in death. Cross-trait linkage disequilibrium score regression was used to estimate genetic correlations of critical COVID-19 with ischemic stroke, other related cardiovascular outcomes, and risk factors common to both COVID-19 and cardiovascular disease (body mass index, smoking and chronic inflammation, estimated using C-reactive protein). Mendelian randomization analysis was performed to investigate whether liability to

SUBMITTER: Zuber V 

PROVIDER: S-EPMC8751930 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature