Derivation and Validation of Genome-Wide Polygenic Score for Ischemic Heart Failure.

ABSTRACT: Background Despite advances in cardiovascular disease and risk factor management, mortality from ischemic heart failure (HF) in patients with coronary artery disease (CAD) remains high. Given the partial role of genetics in HF and lack of reliable risk stratification tools, we developed and validated a polygenic risk score for HF in patients with CAD, which we term HF-PRS. Methods and Results Using summary statistics from a recent genome-wide association study for HF, we developed candidate PRSs in the Mount Sinai BioMe CAD patient cohort (N=6274) by using the pruning and thresholding method and LDPred. We validated the best score in the Penn Medicine BioBank (N=7250) and performed a subgroup analysis in a high-risk cohort who had undergone coronary catheterization. We observed a si

SUBMITTER: Paranjpe I 

PROVIDER: S-EPMC8751935 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature