Mycolicibacterium fortuitum genomic epidemiology, resistome and virulome.

ABSTRACT:

Background

Mycolicibacterium fortuitum is an opportunistic pathogen associated with human and animal infection worldwide. Studies concerning this species are mainly represented by case reports, some of them addressing drug susceptibility with a focus on a specific geographic region, so there is a gap in relation to the global epidemiological scenario.

Objectives

We aimed determine the global epidemiological scenario of M. fortuitum and analyse its traits associated with pathogenicity.

Methods

Based on publicly available genomes of M. fortuitum and a genome from Brazil (this study), we performed a genomic epidemiology analysis and in silico and in vitro characterisation of the resistome and virulome of this species.

Findings

Three main clusters were defined, one

SUBMITTER: Morgado S 

PROVIDER: S-EPMC8752049 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature