Pharmacometric analysis of seasonal influenza epidemics and the effect of vaccination using sentinel surveillance data.

ABSTRACT: The identification of influenza epidemics and assessment of the efficacy of vaccination against this infection are major challenges for the implementation of effective public health strategies, such as vaccination programs. In this study, we developed a new pharmacometric model to evaluate the efficacy of vaccination based on infection surveillance data from the 2010/2011 to 2018/2019 influenza seasons in Japan. A novel susceptible-infected-removed plus vaccination model, based on an indirect response structure with the effect of vaccination, was applied to describe seasonal influenza epidemics using a preseasonal collection of data regarding serological H₁ antibody titer positivity and the fraction of virus strains. Using this model, we evaluated K_in (a parameter des

SUBMITTER: Otani Y 

PROVIDER: S-EPMC8752114 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature