A Dual, Systematic Approach to Malaria Diagnostic Biomarker Discovery.

ABSTRACT:

Background

The emergence and spread of Plasmodium falciparum parasites that lack HRP2/3 proteins and the resulting decreased utility of HRP2-based malaria rapid diagnostic tests (RDTs) prompted the World Health Organization and other global health stakeholders to prioritize the discovery of novel diagnostic biomarkers for malaria.

Methods

To address this pressing need, we adopted a dual, systematic approach by conducting a systematic review of the literature for publications on diagnostic biomarkers for uncomplicated malaria and a systematic in silico analysis of P. falciparum proteomics data for Plasmodium proteins with favorable diagnostic features.

Results

Our complementary analyses led us to 2 novel malaria diagnostic biomarkers compatible for use in an RDT format

SUBMITTER: Yerlikaya S 

PROVIDER: S-EPMC8752250 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature