Identification of Immune-Related Prognostic mRNA and lncRNA in Patients with Hepatocellular Carcinoma.

ABSTRACT:

Background

As the most common hepatic malignancy, hepatocellular carcinoma (HCC) has a high incidence; therefore, in this paper, the immune-related genes were sought as biomarkers in liver cancer.

Methods

In this study, a differential expression analysis of lncRNA and mRNA in The Cancer Genome Atlas (TCGA) dataset between the HCC group and the normal control group was performed. Enrichment analysis was used to screen immune-related differentially expressed genes. Cox regression analysis and survival analysis were used to determine prognostic genes of HCC, whose expression was detected by molecular experiments. Finally, important immune cells were identified by immune cell infiltration and detected by flow cytometry.

Results

Compared with the normal group, 1613 differe

SUBMITTER: Chen D 

PROVIDER: S-EPMC8752260 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature