Building Structural Models of a Whole Mycoplasma Cell.

ABSTRACT: Building structural models of entire cells has been a long-standing cross-discipline challenge for the research community, as it requires an unprecedented level of integration between multiple sources of biological data and enhanced methods for computational modeling and visualization. Here, we present the first 3D structural models of an entire Mycoplasma genitalium (MG) cell, built using the CellPACK suite of computational modeling tools. Our model recapitulates the data described in recent whole-cell system biology simulations and provides a structural representation for all MG proteins, DNA and RNA molecules, obtained by combining experimental and homology-modeled structures and lattice-based models of the genome. We establish a framework for gathering, curating and evaluating these st

SUBMITTER: Maritan M 

PROVIDER: S-EPMC8752489 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature