Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations.

ABSTRACT: Functional precision medicine is a strategy whereby live tumor cells from affected individuals are directly perturbed with drugs to provide immediately translatable, personalized information to guide therapy. The heterogeneity of human cancer has led to the realization that personalized approaches are needed to improve treatment outcomes. Precision oncology has traditionally used static features of the tumor to dictate which therapies should be used. Static features can include expression of key targets or genomic analysis of mutations to identify therapeutically targetable "drivers." Although a surprisingly small proportion of individuals derive clinical benefit from the static approach, functional precision medicine can provide additional information regarding tumor vulnerabilities. We d

SUBMITTER: Letai A 

PROVIDER: S-EPMC8752507 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature