Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling.

ABSTRACT: Accurate chromosome segregation during cell division requires amphitelic chromosome attachment to the spindle apparatus. It is ensured by the combined activity of the spindle assembly checkpoint (SAC),¹ a signaling mechanism that delays anaphase onset in response to unattached chromosomes, and an error correction mechanism that eliminates syntelic attachments.² The SAC becomes active when Mps1 kinase sequentially phosphorylates the kinetochore protein Spc105/KNL1 and the signaling proteins that Spc105/KNL1 recruits to facilitate the production of the mitotic checkpoint complex (MCC).^3-8 The error correction mechanism is regulated by the Aurora B kinase, but Aurora B also promotes SAC signaling via indirect mechanisms.^9-12 Here we present evidence

SUBMITTER: Roy B 

PROVIDER: S-EPMC8752509 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature