Survival predictors of ¹⁷⁷Lu-Dotatate peptide receptor radionuclide therapy (PRRT) in patients with progressive well-differentiated neuroendocrine tumors (NETS).

ABSTRACT:

Purpose

¹⁷⁷Lu-Dotatate is an emerging treatment modality for patients with unresectable or metastatic well-differentiated NETs. This study examines survival predictors in patients who received ¹⁷⁷Lu-Dotatate.

Methods

A retrospective single-center review was conducted, examining 47 individuals with progressive well-differentiated NETs treated with ¹⁷⁷Lu-Dotatate (four induction cycles of 5.5 GBq at 10-week intervals followed by eight maintenance cycles of 3.7 GBq at 6-month intervals).

Results

Median follow-up was 63.1 months with a median progression-free survival (PFS) of 34.1 months. However, median overall survival (OS) was not reached at the time of analysis. The presence of ≥ 5 bone metastases (hazard ratio HR 4.33; p = 0.015), no

SUBMITTER: Swiha MM 

PROVIDER: S-EPMC8752529 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature