Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens.

ABSTRACT: Depression is the leading cause of disability and produces enormous health and economic burdens. Current treatment approaches for depression are largely ineffective and leave more than 50% of patients symptomatic, mainly because of non-selective and broad action of antidepressants. Thus, there is an urgent need to design and develop novel therapeutics to treat depression. Given the heterogeneity and complexity of the brain, identification of molecular mechanisms within specific cell-types responsible for producing depression-like behaviors will advance development of therapies. In the reward circuitry, the nucleus accumbens (NAc) is a key brain region of depression pathophysiology, possibly based on differential activity of D1- or D2- medium spiny neurons (MSNs). Here we report a circuit-

SUBMITTER: Kim HD 

PROVIDER: S-EPMC8752624 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature