Non-invasive Detection of Immunotherapy-Induced Adverse Events.

ABSTRACT:

Purpose

Cancer immunotherapy has markedly improved the prognosis of patients with a broad variety of malignancies. However, benefits are weighed against unique toxicities, with immune-related adverse events (irAE) that are frequent and potentially life-threatening. The diagnosis and management of these events are challenging due to heterogeneity of timing onset, multiplicity of affected organs, and lack of non-invasive monitoring techniques. We demonstrate the use of a granzyme B-targeted PET imaging agent (GZP) for irAE identification in a murine model.

Experimental design

We generated a model of immunotherapy-induced adverse events in Foxp3-DTR-GFP mice bearing MC38 tumors. GZP PET imaging was performed to evaluate organs non-invasively. We validated imaging with ex vivo a

SUBMITTER: Ferreira CA 

PROVIDER: S-EPMC8752648 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature