RegEnrich gene regulator enrichment analysis reveals a key role of the ETS transcription factor family in interferon signaling.

ABSTRACT: Changes in a few key transcriptional regulators can lead to different biological states. Extracting the key gene regulators governing a biological state allows us to gain mechanistic insights. Most current tools perform pathway/GO enrichment analysis to identify key genes and regulators but tend to overlook the gene/protein regulatory interactions. Here we present RegEnrich, an open-source Bioconductor R package, which combines differential expression analysis, data-driven gene regulatory network inference, enrichment analysis, and gene regulator ranking to identify key regulators using gene/protein expression profiling data. By benchmarking using multiple gene expression datasets of gene silencing studies, we found that RegEnrich using the GSEA method to rank the regulators performed the

SUBMITTER: Tao W 

PROVIDER: S-EPMC8752721 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature