Impact of age at onset on symptom profiles, treatment characteristics and health-related quality of life in Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is typically considered an age-related disease, but the age at disease onset can vary by decades between patients. Aging and aging-associated diseases can affect the movement system independently of PD, and advanced age has previously been proposed to be associated with a more severe PD phenotype with accelerated progression. In this work, we investigated how interactions between PD progression and aging affect a wide range of outcomes related to PD motor and nonmotor symptoms as well as Health Related Quality of Life (HRQoL) and treatment characteristics. This population-based cohort study is based on 1436 PD patients from southern Sweden followed longitudinally for up to approximately 7.5 years from enrollment (3470 visits covering 2285 patient years, average fol

SUBMITTER: Raket LL 

PROVIDER: S-EPMC8752787 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature