Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy.

ABSTRACT: Decades of advancements in immuno-oncology have enabled the development of current immunotherapies, which provide long-term treatment responses in certain metastatic cancer patients. However, cures remain infrequent, and most patients ultimately succumb to treatment-refractory metastatic disease. Recent insights suggest that tumors at certain organ sites exhibit distinctive response patterns to immunotherapy and can even reduce antitumor immunity within anatomically distant tumors, suggesting the activation of tissue-specific immune tolerogenic mechanisms in some cases of therapy resistance. Specialized immune cells known as regulatory T cells (Tregs) are present within all tissues in the body and coordinate the suppression of excessive immune activation to curb autoimmunity and maintain i

SUBMITTER: Huppert LA 

PROVIDER: S-EPMC8752797 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature