Community-acquired pneumonia subgroups and differential response to corticosteroids: a secondary analysis of controlled studies.

ABSTRACT:

Background

Latent class analysis (LCA) has identified subgroups with meaningful treatment implications in acute respiratory distress syndrome. We performed a secondary analysis of three studies to assess whether LCA can identify clinically distinct subgroups in community-acquired pneumonia (CAP) and whether the treatment effect of adjunctive corticosteroids differs between subgroups.

Methods

LCA was performed on baseline clinical and biomarker data from the Ovidius trial (n=304) and the Steroids in Pneumonia (STEP) trial (n=727), both randomised controlled trials investigating adjunctive corticosteroid treatment in CAP, and the observational TripleP cohort (n=201). Analyses were conducted independently in two cohorts (Ovidius-TripleP combined and the STEP trial). In both coh

SUBMITTER: Wittermans E 

PROVIDER: S-EPMC8752939 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature