Recording brain responses to TMS of primary motor cortex by EEG - utility of an optimized sham procedure.

ABSTRACT:

Introduction

Electroencephalography (EEG) is increasingly used to investigate brain responses to transcranial magnetic stimulation (TMS). A relevant issue is that TMS is associated with considerable auditory and somatosensory stimulation, causing peripherally evoked potentials (PEPs) in the EEG, which contaminate the direct cortical responses to TMS (TEPs). All previous attempts to control for PEPs suffer from significant limitations.

Objective/hypothesis

To design an optimized sham procedure to control all sensory input generated by subthreshold real TMS targeting the hand area of the primary motor cortex (M1), enabling reliable separation of TEPs from PEPs.

Methods

In 23 healthy (16 female) subjects, we recorded EEG activity evoked by an optimized sham TMS condition

SUBMITTER: Gordon PC 

PROVIDER: S-EPMC8752966 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature