Validation and genetic heritability estimation of known type 2 diabetes related variants in the Korean population.

ABSTRACT: Genome-wide association studies (GWASs) facilitated the discovery of countless disease-associated variants. However, GWASs have mostly been conducted in European ancestry samples. Recent studies have reported that these European-based association results may reduce disease prediction accuracy when applied in non-Europeans. Therefore, previously reported variants should be validated in non-European populations to establish reliable scientific evidence for precision medicine. In this study, we validated known associations with type 2 diabetes (T2D) and related metabolic traits in 125,850 samples from a Korean population genotyped by the Korea Biobank Array (KBA). At the end of December 2020, there were 8,823 variants associated with glycemic traits, lipids, liver enzymes, and T2D in the GWAS

SUBMITTER: Jang HM 

PROVIDER: S-EPMC8752982 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature