Genetic analysis of the postsynaptic transmembrane X-linked neuroligin 3 gene in autism.

ABSTRACT: Autism is a complex neurodevelopmental disorder, the prevalence of which has increased drastically in India in recent years. Neuroligin is a type I transmembrane protein that plays a crucial role in synaptogenesis. Alterations in synaptic genes are most commonly implicated in autism and other cognitive disorders. The present study investigated the neuroligin 3 gene in the Indian autistic population by sequencing and in silico pathogenicity prediction of molecular changes. In total, 108 clinically described individuals with autism were included from the North Karnataka region of India, along with 150 age-, sex-, and ethnicity-matched healthy controls. Genomic DNA was extracted from peripheral blood, and exonic regions were sequenced. The functional and structural effects of variants of the

SUBMITTER: Hegde R 

PROVIDER: S-EPMC8752989 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature