Dynamic Expression and Chromatin Incorporation of ACT and CREM Transcription Factors in Testis Tissues of Infertile Men.

ABSTRACT:

Objective

Activator of CREM in the testis (ACT) is a tissue specific transcription factor which activates cAMP responsive element modulator (CREM), a key transcription factor in differentiation of round spermatids into mature spermatozoa. They bind to CRE region in the promoters of transition protein genes (TNP1, TNP2) and protamine genes (PRM1 and PRM2), which are essential for sperm chromatin compaction, and regulates their transcription. This study was conducted to consider the expression of ACT and CREM and their regulatory roles on the expression of PRM1, PRM2, TNP1 and TNP2 genes in testis tissues of infertile men.

Materials and methods

In this case-control study, testicular biopsies were collected from 40 infertile men and classified

SUBMITTER: Jazireian P 

PROVIDER: S-EPMC8753101 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature