Gynecologic and obstetric management of women with von Willebrand disease: summary of 3 systematic reviews of the literature.

ABSTRACT: von Willebrand disease (VWD) disproportionately affects women because of the potential for heavy menstrual bleeding (HMB), delivery complications, and postpartum hemorrhage (PPH). To systematically synthesize the evidence regarding first-line management of HMB, treatment of women requiring or desiring neuraxial analgesia, and management of PPH. We searched Medline and EMBASE through October 2019 for randomized trials, comparative observational studies, and case series comparing the effects of desmopressin, hormonal therapy, and tranexamic acid (TxA) on HMB; comparing different von Willebrand factor (VWF) levels in women with VWD who were undergoing labor and receiving neuraxial anesthesia; and measuring the effects of TxA on PPH. We conducted duplicate study selection, data abstraction, an

SUBMITTER: Brignardello-Petersen R 

PROVIDER: S-EPMC8753192 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature