Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression.

ABSTRACT: Numerous studies have been performed over the last decade to exploit the complexity of genomic and transcriptomic lesions driving the initiation of acute myeloid leukemia (AML). These studies have helped improve risk classification and treatment options. Detailed molecular characterization of longitudinal AML samples is sparse, however; meanwhile, relapse and therapy resistance represent the main challenges in AML care. To this end, we performed transcriptome-wide RNA sequencing of longitudinal diagnosis, relapse, and/or primary resistant samples from 47 adult and 23 pediatric AML patients with known mutational background. Gene expression analysis revealed the association of short event-free survival with overexpression of GLI2 and IL1R1, as well as downregulation of ST18. Moreover, CR1 do

SUBMITTER: Stratmann S 

PROVIDER: S-EPMC8753201 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature