Von Willebrand factor levels in the diagnosis of von Willebrand disease: a systematic review and meta-analysis.

ABSTRACT: von Willebrand disease (VWD) is associated with significant morbidity as a result of excessive mucocutaneous bleeding. Early diagnosis and treatment are important to prevent and treat these symptoms. We systematically reviewed the accuracy of diagnostic tests using different cutoff values of von Willebrand factor antigen (VWF:Ag) and platelet-dependent von Willebrand factor (VWF) activity assays in the diagnosis of VWD. We searched Cochrane Central Register for Controlled Trials, MEDLINE, and Embase databases for eligible studies. We pooled estimates of sensitivity and specificity and reported patient-important outcomes when relevant. This review included 21 studies that evaluated VWD diagnosis. The results showed low certainty in the evidence for a net health benefit from reconsidering th

SUBMITTER: Kalot MA 

PROVIDER: S-EPMC8753202 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature