Predictive Significance of Promoter DNA Methylation of <i>Cysteine Dioxygenase Type 1 (CDO1)</i> in Metachronous Gastric Cancer.

ABSTRACT:

Purpose

Promoter DNA methylation of various genes has been associated with metachronous gastric cancer (MGC). The cancer-specific methylation gene, cysteine dioxygenase type 1 (CDO1), has been implicated in the occurrence of residual gastric cancer. We evaluated whether DNA methylation of CDO1 could be a predictive biomarker of MGC using specimens of MGC developing on scars after endoscopic submucosal dissection (ESD).

Materials and methods

CDO1 methylation values (TaqMeth values) were compared between 33 patients with early gastric cancer (EGC) with no confirmed metachronous lesions at >3 years after ESD (non-MGC: nMGC group) and 11 patients with MGC developing on scars after ESD (MGCSE groups: EGC at the first ESD [MGCSE-1 group], EGC at the second ESD

SUBMITTER: Kubota Y 

PROVIDER: S-EPMC8753284 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature