Association between long-term oxygen therapy provided outside the guidelines and mortality in patients with COPD.

ABSTRACT:

Introduction

Hypoxaemia is a frequent complication of chronic obstructive pulmonary disease (COPD). To prevent its consequences, supplemental oxygen therapy is recommended by international respiratory societies. However, despite clear recommendations, some patients receive long-term oxygen therapy (LTOT), while they do not meet prescription criteria. While evidence suggests that acute oxygen supply at high oxygenation targets increases COPD mortality, its chronic effects on COPD mortality remain unclear. Thus, the study will aim to evaluate through a systematic review and individual patient data meta-analysis (IPD-MA), the association of LTOT prescription outside the guidelines on survival over time in COPD.

Methods

Systematic review and IPD-MA will be conducted according to

SUBMITTER: Alexandre F 

PROVIDER: S-EPMC8753397 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature