Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia.

ABSTRACT:

Background

The powerful 'graft versus leukemia' effect thought partly responsible for the therapeutic effect of allogeneic hematopoietic cell transplantation in acute myeloid leukemia (AML) provides rationale for investigation of immune-based therapies in this high-risk blood cancer. There is considerable preclinical evidence for potential synergy between PD-1 immune checkpoint blockade and the hypomethylating agents already commonly used for this disease.

Methods

We report here the results of 17 H-0026 (PD-AML, NCT02996474), an investigator sponsored, single-institution, single-arm open-label 10-subject pilot study to test the feasibility of the first-in-human combination of pembrolizumab and decitabine in adult patients with refractory or relapsed AML (R-AML).

Results</

SUBMITTER: Goswami M 

PROVIDER: S-EPMC8753450 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature