Analytical performance validation and clinical application of blood gas analyzer on the detection of neonatal bilirubin.

ABSTRACT:

Background

It is not yet clear whether the trace blood gas analyzer can be used for biochemical detection of newborns. This study aimed to evaluate the reliability of the method for the detection of bilirubin in infants.

Methods

Based on the Clinical and Laboratory Standards Institute (CLSI) EP15-A2 document, the analytical performance of the blood gas analyzer method for bilirubin detection in neonates was validated. The resulting data of 363 simultaneous bilirubin detection with blood gas analyzer (optical method) and biochemical analyzer (enzymatic method) were reviewed. According to the CLSI EP9-A3 document, the relevance and consistency of the measurement results were evaluated by Pearson correlation analysis, Passing-Bablok regression, and Bland-Altman deviation analys

SUBMITTER: Kuang Z 

PROVIDER: S-EPMC8753479 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature