Recent progress (2015-2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb₁, a main active ingredient in Panax ginseng Meyer.

ABSTRACT: Ginsenoside Rb₁ (Rb₁), one of the most important ingredients in Panax ginseng Meyer, has been confirmed to have favorable activities, including reducing antioxidative stress, inhibiting inflammation, regulating cell autophagy and apoptosis, affecting sugar and lipid metabolism, and regulating various cytokines. This study reviewed the recent progress on the pharmacological effects and mechanisms of Rb₁ against cardiovascular and nervous system diseases, diabetes, and their complications, especially those related to neurodegenerative diseases, myocardial ischemia, hypoxia injury, and traumatic brain injury. This review retrieved articles from PubMed and Web of Science that were published from 2015 to 2020. The molecular targets or pathways of the effe

SUBMITTER: Lin Z 

PROVIDER: S-EPMC8753521 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature