Horizontal transfer and evolution of wall teichoic acid gene cassettes in  Bacillus subtilis.

ABSTRACT: Background: Wall teichoic acid (WTA) genes are essential for production of cell walls in gram-positive bacteria and necessary for survival and variability in the cassette has led to recent antibiotic resistance acquisition in pathogenic bacteria.  Methods: Using a pan-genome approach, we examined the evolutionary history of WTA genes in  Bacillus subtilis ssp.  subtilis.  Results: Our analysis reveals an interesting pattern of evolution from the type-strain WTA gene cassette possibly resulting from horizontal acquisition from organisms with similar gene sequences. The WTA cassettes have a high level of variation which may be due to one or more independent horizontal transfer events during the evolution of  Bacillus subtilis ssp.  subtilis. T

SUBMITTER: Sutton G 

PROVIDER: S-EPMC8753576 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature