Sex differences in sucrose reinforcement in Long-Evans rats.

ABSTRACT:

Background

There are sex differences in addiction behaviors. To develop a pre-clinical animal model to investigate this, the present study examined sex differences in sucrose taking and seeking using Long-Evans rats.

Methods

Five experiments were conducted using separate groups of subjects. The first two examined sucrose or saccharin preference in two-bottle home cage choice tests. Experiment three assessed sucrose intake in a binge model with sucrose available in home cage bottles. Experiments four and five utilized operant-based procedures. In experiment four rats responded for sucrose on fixed and progressive ratio (FR, PR) schedules of reinforcement over a range of concentrations of sucrose. A final component of experiment four was measuring seeking in the absence of suc

SUBMITTER: Grimm JW 

PROVIDER: S-EPMC8753819 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature