Association of SMAD7 genetic markers and haplotypes with colorectal cancer risk.

ABSTRACT:

Purpose

Colorectal cancer (CRC) is one of the common cancers with a high mortality rate worldwide. In Iran, there has been a trend of increased incidence of colorectal cancer in the last three decades that necessitates the early diagnosis. Genetic factors have an influential role in its etiology along with the conventional risk factors such as age, diet, and lifestyle. Results from GWAS have shown significant associations between SMAD7 gene variants and risk of CRC. This study aimed to assess the association of certain polymorphisms as well as haplotypes of this gene and risk of colorectal cancer.

Methods and materials

This study was designed as a case-control association study. After obtaining ethical approval and informed consent, blood samples from 209 patients with color

SUBMITTER: Alidoust M 

PROVIDER: S-EPMC8753827 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature