Identification and validation of the high expression of pseudogene TCAM1P in cervical cancer via integrated bioinformatics analysis.

ABSTRACT:

Background

HPV as the main cause of cervical cancer has long been revealed, but the detailed mechanism has not yet been elucidated. The role of testis/cancer antigen in cervical cancer has been revealed. However, there are no reports about the statement of testis/cancer-specific non-coding RNA. In this study, we first proposed TCAM1P as a testis/cancer-specific pseudogene, and used a series of experimental data to verify its relationship with HPV, and analyzed its diagnosis value of high-grade cervical lesions and the mechanism of their high expression in cervical cancer. This provides a new direction for the prevention and treatment of cervical cancer.

Methods

The specific expression of pseudogenes in each tissue was calculated by "TAU" formula. ROC curve was used to judge

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC8753837 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature