Utilizing the MEST score for prognostic staging in IgA nephropathy.

ABSTRACT:

Background

The Oxford classification/MEST score is an established histopathologic scoring system for patients with IgA nephropathy (IgAN). The objective of this study was to derive a prognostic model for IgAN based on the MEST score and histopathologic features.

Methods

A total of 306 patients with biopsy-proven primary IgAN were included. Histopathologic samples were retrieved from the Norwegian Kidney Biopsy Registry and reclassified according to the Oxford classification. The study endpoint was end-stage renal disease (ESRD). Patients were subclassified into three risk models based on histologic features (Model A), a composite score calculated from the adjusted hazard ratio values (Model B), and on quartiles (Model C).

Results

The mean follow-up time was 16.5 years

SUBMITTER: Haaskjold YL 

PROVIDER: S-EPMC8753851 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature