Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.

ABSTRACT:

Background

Genetic and lifestyle factors have considerable effects on obesity and related diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank examined associations of a BMI polygenic risk score (PRS), and its interactions with lifestyle risk factors, with clinically measured BMI and clinical phenotypes.

Methods

The Mass General Brigham (MGB) Biobank is a hospital-based cohort with electronic health record, genetic, and lifestyle data. A PRS for obesity was generated using 97 genetic variants for BMI. An obesity lifestyle risk index using survey responses to obesogenic lifestyle risk factors (alcohol, education, exercise, sleep, smoking, and shift work) was used to dichotomize the cohort into high and low obesogenic index based on the

SUBMITTER: Dashti HS 

PROVIDER: S-EPMC8753909 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature