Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron system associated with both genetic and environmental risk factors. Infection with enteroviruses, including poliovirus and coxsackievirus, such as coxsackievirus B3 (CVB3), has been proposed as a possible causal/risk factor for ALS due to the evidence that enteroviruses can target motor neurons and establish a persistent infection in the central nervous system (CNS), and recent findings that enteroviral infection-induced molecular and pathological phenotypes closely resemble ALS. However, a causal relationship has not yet been affirmed.

Methods

Wild-type C57BL/6J and G85R mutant superoxide dismutase 1 (SOD1^G85R) ALS mice were intracerebroventricularly infected w

SUBMITTER: Xue YC 

PROVIDER: S-EPMC8753920 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature