The association between transfer coefficient of the lung and the risk of exacerbation in asthma-COPD overlap: an observational cohort study.

ABSTRACT:

Background

Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) patients experience exacerbations more frequently than those with asthma or COPD alone. Since low diffusing capacity of the lung for carbon monoxide (D_LCO) is known as a strong risk factor for severe exacerbation in COPD, D_LCO or a transfer coefficient of the lung for carbon monoxide (K_CO) is speculated to also be associated with the risk of exacerbations in ACO.

Methods

This study was conducted as an observational cohort survey at the National Hospital Organization Fukuoka National Hospital. D_LCO and K_CO were measured in 94 patients aged ≥ 40 years with a confirmed diagnosis of ACO. Multivariable-adjusted hazard ratios (HRs) for the exacerbatio

SUBMITTER: Ogata H 

PROVIDER: S-EPMC8753934 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature