Functional reserve: The residual variance in instrumental activities of daily living not explained by brain structure, cognition, and demographics.

ABSTRACT:

Objective

Cognitive reserve is a concept that explains individual differences in resilience to brain pathology and susceptibility to poor late-life cognitive outcomes. We evaluate the analogous concept of "Functional Reserve," defined as the difference between observed functional abilities and those predicted by brain structure, cognitive performance, and demographics. This study aims to validate the construct of functional reserve by testing its utility in predicting clinical outcomes and exploring its predictors.

Method

Longitudinal data collected annually for up to 7 years from 1,084 older adults (ndementia = 163; nMCI = 333; nCN = 523) were analyzed. Functional reserve was operationalized as the residual variance in the Lawton-Brody Instrumental Activities of Daily Livin

SUBMITTER: Kraal AZ 

PROVIDER: S-EPMC8753970 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature