Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish.

ABSTRACT: Protein tyrosine phosphatase receptor-ζ1 (PTPRZ1) is a transmembrane tyrosine phosphatase receptor highly expressed in embryonic stem cells. In the present work, gene expression analyses of Ptprz1^-/- and Ptprz1^+/+ mice endothelial cells and hearts pointed to an unidentified role of PTPRZ1 in heart development through the regulation of heart-specific transcription factor genes. Echocardiography analysis in mice identified that both systolic and diastolic functions are affected in Ptprz1^-/- compared with Ptprz1^+/+ hearts, based on a dilated left ventricular (LV) cavity, decreased ejection fraction and fraction shortening, and increased angiogenesis in Ptprz1^-/- hearts, with no signs of cardiac hy

SUBMITTER: Katraki-Pavlou S 

PROVIDER: S-EPMC8754060 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature