Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles.

ABSTRACT: The generation of oxidative stress by ambient air pollution particles contributes to the development of allergic sensitization and asthma, as demonstrated by intranasal challenge with well-characterized diesel exhaust particle (DEP) suspensions in humans. This effect is due to the presence of redox active organic chemicals in DEP, and can be suppressed by antioxidants and inducers of phase II enzymes in animals. In this communication, we determined whether the administration of a standardized broccoli sprout extract (BSE), which contains a reproducible amount of the sulforaphane (SFN) precursor, glucoraphanin, could be used to suppress the nasal inflammatory response in human subjects challenged with 300 μg of an aqueous DEP suspension (equivalent to daily PM exposure levels on a Los Angel

SUBMITTER: Heber D 

PROVIDER: S-EPMC8754169 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature