Genetic Influence on Nociceptive Processing in the Human Brain-A Twin Study.

ABSTRACT: Nociceptive processing in the human brain is complex and involves several brain structures and varies across individuals. Determining the structures that contribute to interindividual differences in nociceptive processing is likely to improve our understanding of why some individuals feel more pain than others. Here, we found specific parts of the cerebral response to nociception that are under genetic influence by employing a classic twin-design. We found genetic influences on nociceptive processing in the midcingulate cortex and bilateral posterior insula. In addition to brain activations, we found genetic contributions to large-scale functional connectivity (FC) during nociceptive processing. We conclude that additive genetics influence specific brain regions involved in nociceptive pro

SUBMITTER: Kastrati G 

PROVIDER: S-EPMC8754385 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature