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Peroxisome function relies on organelle-associated mRNA translation.

ABSTRACT: [Figure: see text].

SUBMITTER: Dahan N

PROVIDER: S-EPMC8754406 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Peroxisome function relies on organelle-associated mRNA translation

Project description:Crucial metabolic functions of peroxisomes rely on a variety of peroxisomal membrane proteins (PMPs). While mRNA transcripts of PMPs were shown to be colocalized with peroxisomes, the process by which PMPs efficiently couple translation with targeting to the peroxisomal membrane remained elusive. Here, we combine quantitative electron microscopy with proximity-specific ribosome profiling and reveal that translation of specific PMPs occurs on the surface of peroxisomes in the yeast Saccharomyces cerevisiae. This places peroxisomes alongside chloroplasts, mitochondria, and the endoplasmic reticulum as organelles that use localized translation for ensuring correct insertion of hydrophobic proteins into their membranes. Moreover, the correct targeting of these transcripts to peroxisomes is crucial for peroxisomal and cellular function, emphasizing the importance of localized translation for cellular physiology.

2022-01-12 | GSE113567 | GEO